Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells
نویسندگان
چکیده
منابع مشابه
Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells
Neoantigens are the main targets of tumor-specific T cells reactivated by immune checkpoint-blocking antibodies or when using tumor-infiltrating T cells for adoptive therapy. While cancers often accumulate hundreds of mutations and harbor several immunogenic neoantigens, the repertoire of mutation-specific T cells in patients might be restricted. To bypass suboptimal conditions, which impede th...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.24232